Methanol → HCID 59442119, compound

Participants

Reaction Steps

A solution of 8-bromo-5-{[4-[4-(1-methylethyl)-1-piperazinyl]-2-(methyloxy)phenyl]amino}-3-[(4-methylphenyl)sulfonyl]pyrrolo[2′,3′:4,5]pyrimido[6,1-b]quinazolin-7(3H)-one (120 mg, 0.167 mmol), and potassium carbonate (69.4 mg, 0.502 mmol) in methanol (25 ml) was stirred at room temperature. The reaction was filtered to remove the base, organic layer was filtered through a cotton plug, concentrated by rotary evaporation, adsorbed onto silica gel, and purified by silica gel chromatography (DCM to 10% MeOH/DCM) to give methyl 2-bromo-6-({2-{[4-[4-(1-methylethyl)-1-piperazinyl]-2-(methyloxy)phenyl]amino}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzoate (0.1 g, 80%). ESIMS (M+H)+=748.

Provenance & Evidence