HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,6-Dimethylphenyl)methanol → 2-(2-(3-(2,6-Dimethylbenzyloxy)phenoxy)ethyl)isoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,6-Dimethylphenyl)methanol | HCID 186748 | — |
| Reactant | 2-[2-(3-Hydroxy-phenoxy)-ethyl]-isoindole-1,3-dione | HCID 58027534 | — |
| Product | 2-(2-(3-(2,6-Dimethylbenzyloxy)phenoxy)ethyl)isoindoline-1,3-dione | HCID 67317099 | — |
Reaction Steps
Mitsunobu reaction of phenol 24 with 2,6-dimethylbenzyl alcohol gave 2-(2-(3-(2,6-dimethylbenzyloxy)phenoxy)ethyl)isoindoline-1,3-dione as yellow oil. Yield (1.2 g, 85%): 1H NMR (400 MHz, CDCl3) δ 7.85-7.88 (m, 2H), 7.71-7.74 (m, 2H), 7.12-7.18 (m, 1H), 7.01-7.10 (m, 3H), 6.60 (dd, J=8.0, 1.8 Hz, 1H), 6.57 (s, 1H), 6.51 (dd, J=8.0, 1.8 Hz, 1H), 4.99 (s, 2H), 4.09-4.24 (m, 4H), 2.38 (s, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07982071B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-28253cea154d453e9e0d31f55865ba20 |
| Source note | uspto-grants-2011_07 |