反应详情

(S)-6-Bromo-N2-(1-phenylethyl)pyrazine-2,3-diamine. The title compound was prepared using (S)-α-methylbenzylamine (2.28 mL, 17.93 mmol), 2-amino-3,5-dibromo-pyrazine (3.00 g, 11.96 mmol), and n-BuOH (30 mL) as described in General Procedure A. The crude molecule was purified via silica gel chromatography (20-30% EtOAc in hexanes). Clean fractions were combined and condensed, and subsequently triturated from methanol with water while sonicating to afford 1.52 g (5.18 mmol, 43%) of (S)-6-bromo-N2-(1-phenylethyl)pyrazine-2,3-diamine. MS (ESI) m/z 294.0 [M+1]+.

1. customThe crude molecule was purified via silica gel chromatography (20-30% EtOAc in hexanes)
2. customcondensed
3. customsubsequently triturated from methanol with water
4. customwhile sonicating