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HRID1014828

反应详情

EQUATION

反应方程式

HRID 1014828 的结构方程式

REACTANTS

反应物

1
结构：CC1(C)OCc2cc([C@@H](O)CNCCCCCCOCCOCc3cccc(NC(=O)Nc4cccc(NC(=O)c5cccnc5)c4)c3)ccc2O1
HCID66844859

未命名化合物

PRODUCTS

生成物

1
结构：O=C(Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)Nc1cccc(NC(=O)c2cccnc2)c1
HCID10146481

未命名化合物

收率 86.5%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of N-(3-{[({3-[(2-[(6-({(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy}ethoxy)methyl]phenyl}amino)carbonyl]amino)-phenyl)pyridine-3-carboxamide (0.109 g) in acetic acid (4 ml) and water (2 ml) was heated to 68° for 30 min. The mixture was cooled to room temperature before concentrating in vacuo to leave a residue that was purified by Biotage. Elution with dichloromethane-EtOH-ammonia (25:8:1) followed by solvent evaporation in vacuo gave the title compound (0.089 g). LCMS RT=2.02 min, ES+ve 672 (MH)+.

WORKUP

后处理

  1. concentrationbefore concentrating in vacuo
  2. customto leave a residue that
  3. customwas purified by Biotage
  4. washElution with dichloromethane-EtOH-ammonia (25:8:1)
  5. customfollowed by solvent evaporation in vacuo