HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5H-Benzo(6,7)cyclohepta(1,2-d)pyrimidin-2-amine, 4-((3R)-3-amino-1-pyrrolidinyl)-6,7-dihydro-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-((3R)-3-(t-Butoxycarbonyl)Amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine | HCID 59776816 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5H-Benzo(6,7)cyclohepta(1,2-d)pyrimidin-2-amine, 4-((3R)-3-amino-1-pyrrolidinyl)-6,7-dihydro- | HCID 25068753 | — |
Reaction Steps
A solution of the product from Example 4D (68 mg, 0.17 mmol) in CH2Cl2 (3 mL) was treated with trifluoroacetic acid (0.2 mL) and stirred for 16 hours. The mixture was diluted with CH2Cl2, washed H2O, dried, concentrated and chromatographed on silica gel eluting with eluting with NH4OH/MeOH/CH2Cl2 (0.8/8/92) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07985745B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-100f9f366c9d42f7af479d8a5f766996 |
| Source note | uspto-grants-2011_07 |