1-(4-(Benzyloxy)-3-methoxyphenethyl)-4-(3-phenylpropyl)piperazine → HCID 15895837, compound

HRID 1014948Notes

Reaction equation

HRID 1014948 reaction equation
C([O:8][C:9]1[CH:31]=[CH:30][C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:17][CH2:16]2)=[CH:11][C:10]=1[O:32][CH3:33])C1C=CC=CC=1>CO.[Pd]>[CH3:33][O:32][C:10]1[CH:11]=[C:12]([CH2:13][CH2:14][N:15]2[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:19][CH2:20]2)[CH:30]=[CH:31][C:9]=1[OH:8]

Participants

4

Reactant 1

HCID 669850121-(4-(Benzyloxy)-3-methoxyphenethyl)-4-(3-phenylpropyl)piperazine

Product 1

HCID 15895837HCID 15895837, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-(4-(Benzyloxy)-3-methoxyphenethyl)-4-(3-phenylpropyl)piperazine is hydrogenated in 10 mL methanol with 10% Pd/C. The resultant product is then purified by column chromatography, eluting with dichloromethane-methanol (9:1) to afford 95 mg of 1-[2-(3-methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine.

Workup

  1. customThe resultant product is then purified by column chromatography
  2. washeluting with dichloromethane-methanol (9:1)

Sources & evidence

ORD record
ord-2a3b974f03a54735a8ce61fcd2251c7d
Source dataset
uspto-grants-2011_07
Patent number
US07985751B2

Reaction notes

Loading…