Isopropanol → HCID 178463187, compound

Participants

Reaction Conditions

Reaction Steps

To stirred (2R,3R,4R,5R)-2-(2,6-dichloro-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydrofuran-3,4-diyl diacetate (ref WO98/28319A1) (15 g) in propan-2-ol (100 ml) was added N,N-diisopropylethylamine (7.7 ml) and 1,1-dimethylethyl(trans-4-aminocyclohexyl)carbamate (6.82 g). The mixture was stirred at 65° C. for 24 h before cooling to room temperature and concentrating in vacuo. The crude product was purified by column chromatography (silica) eluting with 30% cyclohexane in ethyl acetate. The appropriate fractions were combined and concentrated in vacuo and triturated with diethyl ether to yield the title compound as a white solid, 8.56 g.

Provenance & Evidence