Methanol → HCID 86761364, compound

Participants

Reaction Steps

To a solution of tert-butyl [{1α,3β-bis(tert-butyldimethylsilyloxy)pregna-5,7-dien-20(S)-yl}oxy]acetate (9 mg, 0.013 mmol) in tetrahydrofuran (0.13 ml), a 1M methanol solution of sodium methoxide (0.13 ml) was added and stirred at room temperature for 20 minutes. Water (0.26 ml) was further added and stirred at room temperature for 30 minutes. The reaction mixture was diluted with ethyl acetate, washed with saturated aqueous sodium dihydrogenphosphate, and then dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the titled compound (6 mg, 73%) as a colorless solid.

Provenance & Evidence