Dicyclohexylcarbodiimide → HCID 86761365, compound

Participants

Reaction Steps

[{1α,3β-Bis(tert-butyldimethylsilyloxy)pregna-5,7-dien-20(S)-yl}oxy]acetic acid (91 mg, 0.147 mmol) was treated with 3-pentanol (39 mg, 0.443 mmol), N,N′-dicyclohexylcarbodiimide (61 mg, 0.296 mmol) and 4-(dimethylamino)pyridine (54 mg, 0.443 mmol) in dichloromethane (1.5 ml) in the same manner as shown in Example 17(3) (at room temperature for 15 hours), followed by work up and purification using preparative thin layer chromatography (0.5 mm×3 plates, hexane:ethyl acetate=5:1, developed once) to give the titled compound (37 mg, 37%) as a colorless oil.

Provenance & Evidence