5-Bromoisoquinoline → 5-Bromo-1,2,3,4-tetrahydroisoquinoline

HRID 1014989Notes

Reaction equation

[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[BH4-].[Na+]>>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

Participants

Reactant 2

HCID 7364875-Bromoisoquinoline

HCID 4311764Sodium borohydride

Product 1

HCID 128231995-Bromo-1,2,3,4-tetrahydroisoquinoline

Procedure

In close analogy to the procedure described above, 5-Bromo-isoquinoline is reacted with sodium borohydride to provide the title compound.

Sources & evidence

ORD record: ord-386975036c2f408f935d53de467aca7c
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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