6-Bromoisoquinoline → 6-Bromo-1,2,3,4-tetrahydroisoquinoline

HRID 1014990Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][CH:6]=[CH:5]2.[BH4-].[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6][CH2:5]2

Participants

Reactant 2

HCID 3136816-Bromoisoquinoline

HCID 4311764Sodium borohydride

Product 1

HCID 158851836-Bromo-1,2,3,4-tetrahydroisoquinoline

Procedure

In close analogy to the procedure described above, 6-Bromo-isoquinoline is reacted with sodium borohydride to provide the title compound.

Sources & evidence

ORD record: ord-ad96e4090aed4db9a68d8c3a6837e2a5
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

Loading…