5-Nitroisoquinoline → 5-nitro-1,2,3,4-tetrahydroisoquinoline

HRID 1014991Notes

Reaction equation

[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-:3])=[O:2].[BH4-].[Na+]>>[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][NH:8][CH2:9]2)([O-:3])=[O:2]

Participants

Reactant 2

HCID 690855-Nitroisoquinoline

HCID 4311764Sodium borohydride

Product 1

HCID 113799065-nitro-1,2,3,4-tetrahydroisoquinoline

Procedure

In close analogy to the procedure described above, 5-Nitro-isoquinoline is reacted with sodium borohydride to provide the title compound.

Sources & evidence

ORD record: ord-9b4a0e4ec5294467b1123a43cff239e8
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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