Acetic Anhydride → N-(4-(trifluoromethyl)phenethyl)acetamide

HRID 1015008Notes

Reaction equation

[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH2:11])=[CH:5][CH:4]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[F:1][C:2]([F:12])([F:13])[C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][NH:11][C:14](=[O:16])[CH3:15])=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 19881062-[4-(Trifluoromethyl)phenyl]ethan-1-amine

Product 1

HCID 51072413N-(4-(trifluoromethyl)phenethyl)acetamideYield 29%

Procedure

In close analogy to the procedure described above, 2-(4-trifluoromethyl-phenyl)-ethylamine is reacted with acetic anhydride to provide the title compound.

Sources & evidence

ORD record: ord-b0dfcef0e16a4dabb02034fedff89d40
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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