Acetic Anhydride → N-[2-(2-Trifluoromethyl-phenyl)-ethyl]-acetamide

HRID 1015023Notes

Reaction equation

[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH2:11].[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[F:1][C:2]([F:12])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][C:14](=[O:16])[CH3:15]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 698832-(Trifluoromethyl)phenethylamine

Product 1

HCID 58416419N-[2-(2-Trifluoromethyl-phenyl)-ethyl]-acetamide

Procedure

In close analogy to the procedure described above, 2-(2-trifluoromethyl-phenyl)-ethylamine is reacted with acetic anhydride to provide the title compound.

Sources & evidence

ORD record: ord-ec439cc3d9304fe79d9cbe22792f6000
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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