Phosphorus oxide (P4O10) → 1-Methyl-7-trifluoromethyl-3,4-dihydro-isoquinoline

HRID 1015027Notes

Reaction equation

HRID 1015027 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11][C:12](=O)[CH3:13])=[CH:5][CH:4]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:13][C:12]1[C:7]2[C:6](=[CH:5][CH:4]=[C:3]([C:2]([F:16])([F:15])[F:1])[CH:8]=2)[CH2:9][CH2:10][N:11]=1

Participants

3

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 51072413N-(4-(trifluoromethyl)phenethyl)acetamide

Product 1

HCID 587845091-Methyl-7-trifluoromethyl-3,4-dihydro-isoquinoline

Procedure

In close analogy to the procedure described above, N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Sources & evidence

ORD record
ord-c9893dbfba91410e901854c0f542f5b4
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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