Phosphorus oxide (P4O10) → 7-Bromo-1-methyl-3,4-dihydroisoquinoline

HRID 1015038Notes

Reaction equation

HRID 1015038 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH:10][C:11](=O)[CH3:12])=[CH:4][CH:3]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[Br:1][C:2]1[CH:7]=[C:6]2[C:5]([CH2:8][CH2:9][N:10]=[C:11]2[CH3:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 16097949N-(4-Bromophenethyl)acetamide

Product 1

HCID 186801367-Bromo-1-methyl-3,4-dihydroisoquinoline

Procedure

In close analogy to the procedure described above, N-[2-(4-bromo-phenyl)-ethyl]-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Sources & evidence

ORD record
ord-636a956a3da94def8e65c85eb5ba79dd
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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