Phosphorus oxide (P4O10) → 6-Bromo-1-methyl-3,4-dihydroisoquinoline

HRID 1015039Notes

Reaction equation

HRID 1015039 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][NH:10][C:11](=O)[CH3:12])[CH:5]=[CH:6][CH:7]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[C:11]([CH3:12])=[N:10][CH2:9][CH2:8]2

Participants

3

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 23550251N-[2-(3-Bromo-phenyl)-ethyl]-acetamide

Product 1

HCID 584163806-Bromo-1-methyl-3,4-dihydroisoquinoline

Procedure

In close analogy to the procedure described above, N-[2-(3-bromo-phenyl)-ethyl]-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Sources & evidence

ORD record
ord-ebaa6015648c49b9974328e8c1b2c875
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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