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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1015043Generated: October 31, 2026

Phosphorus oxide (P4O10) → 1-Methyl-5-trifluoromethyl-3,4-dihydro-isoquinoline

https://huagongshe.com/reaction/1015043

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus oxide (P4O10)HCID 14812—
ReactantN-[2-(2-Trifluoromethyl-phenyl)-ethyl]-acetamideHCID 58416419—
Product1-Methyl-5-trifluoromethyl-3,4-dihydro-isoquinolineHCID 58416409—

Reaction Steps

In close analogy to the procedure described above, N-[2-(2-trifluormethyl-phenyl)-ethyl]-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07985753B2
Source datasetuspto-grants-2011_07
ORD IDord-910acacf4562415a826a0a684ee4f614
Source noteuspto-grants-2011_07