Boronic Acid → 5-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline

HRID 1015067Notes

Reaction equation

Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2.B(O)O>>[N:6]1[CH:7]=[CH:8][C:3]([C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH2:4][CH2:5][NH:6][CH2:7]3)=[CH:4][CH:5]=1

Participants

Reactant 2

HCID 61668Boronic Acid

HCID 128231995-Bromo-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 584164715-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline

Procedure

In close analogy to the procedure described above, 5-Bromo-1,2,3,4-tetrahydro-isoquinoline is reacted with the corresponding boronic acid to provide the title compound.

Sources & evidence

ORD record: ord-406c13f1faf3415cb1e5dfbb31b3f4a7
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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