Boronic Acid → 1-Methyl-6-pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline

HRID 1015074Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([CH3:12])[NH:7][CH2:6][CH2:5]2.B(O)O>>[CH3:12][CH:8]1[C:9]2[C:4](=[CH:3][C:2]([C:4]3[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:6][NH:7]1

Participants

Reactant 2

HCID 61668Boronic Acid

HCID 596625906-Bromo-1-methyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 584165131-Methyl-6-pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline

Procedure

In close analogy to the procedure described above, 6-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline is reacted with the corresponding boronic acid to provide the title compound.

Sources & evidence

ORD record: ord-96cce7b256fc4d8f883afe2f26f4ac81
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985753B2

Reaction notes

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