Boronic Acid → 1-Methyl-7-pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline

HRID 1015075Notes

Reaction equation

HRID 1015075 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][NH:8][CH:9]2[CH3:12])=[CH:4][CH:3]=1.B(O)O>>[CH3:12][CH:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([C:5]3[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=3)[CH:11]=2)[CH2:6][CH2:7][NH:8]1

Participants

3

Reactant 2

HCID 61668Boronic AcidHCID 584164221176414-95-1

Product 1

HCID 584165161-Methyl-7-pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline

Procedure

In close analogy to the procedure described above, 7-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline is reacted with the corresponding boronic acid to provide the title compound.

Sources & evidence

ORD record
ord-d6dc87ad5ec44227b55ae2677bdf7b71
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

Loading…