Pyridine, 2-(trimethylstannyl)- → 1-Methyl-6-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline

HRID 1015080Notes

Reaction equation

HRID 1015080 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([CH3:12])[NH:7][CH2:6][CH2:5]2.C[Sn](C)(C)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1>>[CH3:12][CH:8]1[C:9]2[C:4](=[CH:3][C:2]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:6][NH:7]1

Participants

3

Reactant 2

HCID 11021057Pyridine, 2-(trimethylstannyl)-HCID 596625906-Bromo-1-methyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 584163141-Methyl-6-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline

Procedure

In close analogy to the procedure described above, 6-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline is reacted with 2-trimethylstannyl-pyridine to provide the title compound.

Sources & evidence

ORD record
ord-a0cfbf0a35834621918ce94364860d76
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

Loading…