Pyridine, 2-(trimethylstannyl)- → 1-Methyl-5-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline

HRID 1015081Notes

Reaction equation

HRID 1015081 reaction equation
Br[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH:7]2[CH3:12].C[Sn](C)(C)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1>>[CH3:12][CH:7]1[C:8]2[C:3](=[C:2]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:5][NH:6]1

Participants

3

Reactant 2

HCID 11021057Pyridine, 2-(trimethylstannyl)-HCID 596625945-Bromo-1,2,3,4-tetrahydro-1-methylisoquinoline

Product 1

HCID 584163611-Methyl-5-pyridin-2-yl-1,2,3,4-tetrahydro-isoquinoline

Procedure

In close analogy to the procedure described above, 5-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline is reacted with 2-trimethylstannyl-pyridine to provide the title compound.

Sources & evidence

ORD record
ord-0a1d7ce93af742a897924c5e01706cb6
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

Loading…