6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline → HCID 24810080, compound

HRID 1015092Notes

Reaction equation

HRID 1015092 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][C:25]=1[O:26][CH3:27])[CH:22]([CH3:28])[NH:21][CH2:20][CH2:19]2>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:21]3[CH2:20][CH2:19][C:18]4[C:23](=[CH:24][C:25]([O:26][CH3:27])=[C:16]([O:15][CH3:14])[CH:17]=4)[CH:22]3[CH3:28])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 103026,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolineHCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid

Product 1

HCID 24810080HCID 24810080, compound

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-0a5a6b62f85f49d38cf177d8f310e094
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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