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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1015099Generated: October 31, 2026

6,7-Dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline → (6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(6,7-dimethoxy-3-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

https://huagongshe.com/reaction/1015099

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6,7-Dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinolineHCID 22644—
Reactant6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acidHCID 33695678—
Product(6-Chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(6,7-dimethoxy-3-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanoneHCID 24810317—

Reaction Steps

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound as a colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07985753B2
Source datasetuspto-grants-2011_07
ORD IDord-f6ba716fc02b44bcac3420da1f6856db
Source noteuspto-grants-2011_07