6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24810318, compound

HRID 1015100Notes

Reaction equation

HRID 1015100 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][C:25]=1[O:26][CH3:27])[CH2:22][NH:21][C:20]([CH3:29])([CH3:28])[CH2:19]2>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:21]3[C:20]([CH3:29])([CH3:28])[CH2:19][C:18]4[C:23](=[CH:24][C:25]([O:26][CH3:27])=[C:16]([O:15][CH3:14])[CH:17]=4)[CH2:22]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 4339864HCID 4339864, compound

Product 1

HCID 24810318HCID 24810318, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6,7-dimethoxy-3,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound as a colorless solid.

Sources & evidence

ORD record
ord-de96e50dbbe24b1e81b89b37d5a3d280
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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