6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24810320, compound

HRID 1015102Notes

Reaction equation

HRID 1015102 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[C:24]2[N:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:18][CH2:17][NH:16]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[CH:15]([CH3:14])[C:24]4[N:23]=[CH:22][CH:21]=[CH:20][C:19]=4[CH2:18][CH2:17]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66876159HCID 66876159, compound

Product 1

HCID 24810320HCID 24810320, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 8-methyl-5,6,7,8-tetrahydro-[1,7]naphthyridine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-0d9481cb5b03469c8c93b4dddd66269f
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

Loading…