6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24810368, compound

HRID 1015108Notes

Reaction equation

HRID 1015108 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[NH:24][CH2:23][CH2:22][C:21]2[N:20]=[CH:19][CH:18]=[CH:17][C:16]1=2>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:24]3[CH2:23][CH2:22][C:21]4[N:20]=[CH:19][CH:18]=[CH:17][C:16]=4[CH:15]3[CH3:14])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 1319387983081-95-2

Product 1

HCID 24810368HCID 24810368, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 5-methyl-5,6,7,8-tetrahydro-[1,6]naphthyridine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-97941beeda74406bae28f6cb2e3c316c
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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