ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-3-METHYL- → HCID 58416431, compound

HRID 1015137Notes

Reaction equation

HRID 1015137 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][NH:16]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[C@@H:15]([CH3:14])[CH2:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 568974ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-3-METHYL-HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Product 1

HCID 58416431HCID 58416431, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 3-Methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-a749d53383274a658cc13d448414b90c
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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