1-Cyclohexyl-1,2,3,4-tetrahydro-isoquinoline → (6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

HRID 1015150Notes

Reaction equation

HRID 1015150 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH:14]1([CH:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23][CH2:22][NH:21]2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:21]3[CH2:22][CH2:23][C:24]4[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH:20]3[CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 5834531-Cyclohexyl-1,2,3,4-tetrahydro-isoquinolineHCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Product 1

HCID 24810636(6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 1-Cyclohexyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-f70ee206071b49b58623e64536a68198
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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