6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → (6-Bromo-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-(6-bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-methanone

HRID 1015160Notes

Reaction equation

HRID 1015160 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[Br:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]([CH3:25])[NH:20][CH2:19][CH2:18]2>>[Br:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]([CH3:25])[N:20]([C:11]([C:9]1[CH:10]=[C:5]3[N:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]3[N:8]=1)=[O:13])[CH2:19][CH2:18]2

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 596625906-Bromo-1-methyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 24810730(6-Bromo-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-(6-bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-methanone

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-8f8755ee16404bc1b5e5eec2259a9fc1
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

Loading…