6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24810732, compound

HRID 1015162Notes

Reaction equation

HRID 1015162 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[F:14][C:15]1[CH:24]=[CH:23][C:22]([F:25])=[C:21]2[C:16]=1[CH2:17][CH2:18][NH:19][CH:20]2[CH3:26]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:19]3[CH2:18][CH2:17][C:16]4[C:21](=[C:22]([F:25])[CH:23]=[CH:24][C:15]=4[F:14])[CH:20]3[CH3:26])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 62373256HCID 62373256, compound

Product 1

HCID 24810732HCID 24810732, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 5,8-Difluoro-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-0be069798e1d4c8d8e25f28ac67684b7
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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