6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416417, compound

HRID 1015168Notes

Reaction equation

HRID 1015168 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH2:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:24]#[N:25])[CH:22]=2)[CH2:17][CH2:16][NH:15]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:15]3[CH2:16][CH2:17][C:18]4[C:23](=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=4)[CH2:14]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 101762437-Cyano-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 58416417HCID 58416417, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 1,2,3,4-Tetrahydro-isoquinoline-7-carbonitrile to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-5f3bd90b05a74228a7c89442a942f56e
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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