6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 24810838, compound

HRID 1015173Notes

Reaction equation

HRID 1015173 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[N:14]1([C:20]2[CH:29]=[C:28]3[C:23]([CH2:24][CH2:25][NH:26][CH2:27]3)=[CH:22][CH:21]=2)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:26]3[CH2:25][CH2:24][C:23]4[C:28](=[CH:29][C:20]([N:14]5[CH2:19][CH2:18][O:17][CH2:16][CH2:15]5)=[CH:21][CH:22]=4)[CH2:27]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 58416517HCID 58416517, compound

Product 1

HCID 24810838HCID 24810838, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 7-Morpholin-4-yl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-5c9fd4b351ed44538ea8b388578436bd
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

Loading…