6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid → HCID 58416457, compound

HRID 1015180Notes

Reaction equation

HRID 1015180 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[N:14]1([C:20]2[CH:29]=[CH:28][CH:27]=[C:26]3[C:21]=2[CH2:22][CH2:23][NH:24][CH2:25]3)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:24]3[CH2:23][CH2:22][C:21]4[C:26](=[CH:27][CH:28]=[CH:29][C:20]=4[N:14]4[CH2:19][CH2:18][O:17][CH2:16][CH2:15]4)[CH2:25]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acidHCID 66876000HCID 66876000, compound

Product 1

HCID 58416457HCID 58416457, compound

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 5-morpholin-4-yl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-a66931975ac2482e847936788ba7711a
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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