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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1015186Generated: October 30, 2026

6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → (6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-methyl-7-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

https://huagongshe.com/reaction/1015186

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 771938—
Reactant1-Methyl-7-trifluoromethyl-1,2,3,4-tetrahydro-isoquinolineHCID 58784488—
Product(6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-methyl-7-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanoneHCID 5841651518%

Reaction Steps

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 1-Methyl-7-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07985753B2
Source datasetuspto-grants-2011_07
ORD IDord-28391f52fe8246f79297d0446b150bfb
Source noteuspto-grants-2011_07