41629-36-1 → HCID 58416353, compound

HRID 1015194Notes

Reaction equation

HRID 1015194 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH2:14]1[C:23]2[C:18](=[C:19]([NH:24][C:25](=[O:27])[CH3:26])[CH:20]=[CH:21][CH:22]=2)[CH2:17][CH2:16][NH:15]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:15]3[CH2:16][CH2:17][C:18]4[C:23](=[CH:22][CH:21]=[CH:20][C:19]=4[NH:24][C:25](=[O:27])[CH3:26])[CH2:14]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 2189466141629-36-1HCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid

Product 1

HCID 58416353HCID 58416353, compound

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with N-(1,2,3,4-Tetrahydro-isoquinolin-5-yl)-acetamide to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-f86a8d50d13e4d219626857f6b349fed
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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