6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416491, compound

HRID 1015201Notes

Reaction equation

HRID 1015201 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[C:28]2[C:19](=[C:20]3[C:25](=[CH:26][CH:27]=2)[O:24][CH2:23][CH2:22][O:21]3)[CH2:18][CH2:17][NH:16]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[CH:15]([CH3:14])[C:28]4[C:19](=[C:20]5[C:25](=[CH:26][CH:27]=4)[O:24][CH2:23][CH2:22][O:21]5)[CH2:18][CH2:17]3)=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 59662591HCID 59662591, compound

Product 1

HCID 58416491HCID 58416491, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 8-Methyl-2,3,5,6,7,8-hexahydro-1,4-dioxa-7-aza-phenanthrene to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-bc4bdb4d2b3e4d8e855d29d2386d3b98
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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