6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416463, compound

HRID 1015208Notes

Reaction equation

HRID 1015208 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[NH:24][CH2:23][CH2:22][C:21]2[C:16]1=[CH:17][CH:18]=[C:19]1[O:27][CH2:26][O:25][C:20]1=2>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:24]3[CH2:23][CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]5[O:27][CH2:26][O:25][C:20]5=4)[CH:15]3[CH3:14])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 58416480HCID 58416480, compound

Product 1

HCID 58416463HCID 58416463, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 6-Methyl-6,7,8,9-tetrahydro-1,3-dioxa-7-aza-cyclopenta[a]naphthalene to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-d79665f5e6834a4db201052ac618f8d4
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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