6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416426, compound

HRID 1015218Notes

Reaction equation

HRID 1015218 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][O:15][C:16]1[N:21]=[C:20]([O:22][CH3:23])[C:19]([C:24]2[CH:33]=[CH:32][CH:31]=[C:30]3[C:25]=2[CH2:26][CH2:27][NH:28][CH:29]3[CH3:34])=[CH:18][N:17]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:28]3[CH2:27][CH2:26][C:25]4[C:30](=[CH:31][CH:32]=[CH:33][C:24]=4[C:19]4[C:20]([O:22][CH3:23])=[N:21][C:16]([O:15][CH3:14])=[N:17][CH:18]=4)[CH:29]3[CH3:34])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 58416427HCID 58416427, compound

Product 1

HCID 58416426HCID 58416426, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 5-(2,4-Dimethoxy-pyrimidin-5-yl)-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-01b6252136834215b85cb7be63d05863
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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