6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid → HCID 58416370, compound

HRID 1015243Notes

Reaction equation

HRID 1015243 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[F:14][C:15]1[C:20]([C:21]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][NH:27][CH:28]3[CH3:31])=[CH:23][CH:22]=2)=[CH:19][CH:18]=[CH:17][N:16]=1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:27]3[CH2:26][CH2:25][C:24]4[C:29](=[CH:30][C:21]([C:20]5[C:15]([F:14])=[N:16][CH:17]=[CH:18][CH:19]=5)=[CH:22][CH:23]=4)[CH:28]3[CH3:31])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 336956786-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acidHCID 58416348HCID 58416348, compound

Product 1

HCID 58416370HCID 58416370, compound

Procedure

In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 7-(2-Fluoro-pyridin-3-yl)-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-a79013daf053476394dc304c1f34a478
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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