6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416466, compound

HRID 1015246Notes

Reaction equation

HRID 1015246 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[C:19]1[CH:20]=[CH:21][CH:22]=[C:23]2[C:28]=1[CH:27]([CH3:29])[NH:26][CH2:25][CH2:24]2>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:26]3[CH2:25][CH2:24][C:23]4[C:28](=[C:19]([C:15]5[O:14][CH:18]=[CH:17][CH:16]=5)[CH:20]=[CH:21][CH:22]=4)[CH:27]3[CH3:29])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66876135HCID 66876135, compound

Product 1

HCID 58416466HCID 58416466, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 8-Furan-2-yl-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-9e7a0bd4916d46a194c2f251ef331283
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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