6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416439, compound

HRID 1015255Notes

Reaction equation

HRID 1015255 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[O:14]1[CH:18]=[CH:17][C:16]([C:19]2[CH:28]=[C:27]3[C:22]([CH2:23][CH2:24][NH:25][CH:26]3[CH3:29])=[CH:21][CH:20]=2)=[CH:15]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:25]3[CH2:24][CH2:23][C:22]4[C:27](=[CH:28][C:19]([C:16]5[CH:17]=[CH:18][O:14][CH:15]=5)=[CH:20][CH:21]=4)[CH:26]3[CH3:29])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66876625HCID 66876625, compound

Product 1

HCID 58416439HCID 58416439, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 7-Furan-3-yl-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-6f061c5b7c2b4f2589adda13b9776a80
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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