6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416379, compound

HRID 1015257Notes

Reaction equation

HRID 1015257 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[O:14]1[CH:18]=[CH:17][C:16]([C:19]2[CH:28]=[CH:27][CH:26]=[C:25]3[C:20]=2[CH2:21][CH2:22][NH:23][CH:24]3[CH3:29])=[CH:15]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:23]3[CH2:22][CH2:21][C:20]4[C:25](=[CH:26][CH:27]=[CH:28][C:19]=4[C:16]4[CH:17]=[CH:18][O:14][CH:15]=4)[CH:24]3[CH3:29])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66875987HCID 66875987, compound

Product 1

HCID 58416379HCID 58416379, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 5-Furan-3-yl-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-14f49f3fcc09485fb71afc4583e6a1ca
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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