6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416479, compound

HRID 1015259Notes

Reaction equation

HRID 1015259 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][C:15]1[C:19]([C:20]2[CH:29]=[C:28]3[C:23]([CH2:24][CH2:25][NH:26][CH:27]3[CH3:30])=[CH:22][CH:21]=2)=[C:18]([CH3:31])[O:17][N:16]=1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:26]3[CH2:25][CH2:24][C:23]4[C:28](=[CH:29][C:20]([C:19]5[C:15]([CH3:14])=[N:16][O:17][C:18]=5[CH3:31])=[CH:21][CH:22]=4)[CH:27]3[CH3:30])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66876682HCID 66876682, compound

Product 1

HCID 58416479HCID 58416479, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 7-(3,5-Dimethyl-isoxazol-4-yl)-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-d8fe5828f38f431291638f35bd43979d
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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