6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416499, compound

HRID 1015280Notes

Reaction equation

HRID 1015280 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[C:20]2[N:21]=[CH:22][N:23]=[CH:24][C:19]=2[CH2:18][CH2:17][NH:16]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[CH2:17][CH2:18][C:19]4[CH:24]=[N:23][CH:22]=[N:21][C:20]=4[CH:15]3[CH3:14])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66875783HCID 66875783, compound

Product 1

HCID 58416499HCID 58416499, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 8-Methyl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-9cfcba462fc44b1aa8dbf38f9eb1f1a3
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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