6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416313, compound

HRID 1015291Notes

Reaction equation

HRID 1015291 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][S:15]([C:18]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:19]=1[CH2:20][CH2:21][NH:22][CH:23]2[CH3:28])(=[O:17])=[O:16]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:22]3[CH2:21][CH2:20][C:19]4[C:24](=[CH:25][CH:26]=[CH:27][C:18]=4[S:15]([CH3:14])(=[O:16])=[O:17])[CH:23]3[CH3:28])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66876641HCID 66876641, compound

Product 1

HCID 58416313HCID 58416313, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 5-Methanesulfonyl-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-1fed7c42f78949a1b579da13a364785c
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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