6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416490, compound

HRID 1015294Notes

Reaction equation

HRID 1015294 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][S:15]([C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:27]=1[CH:26]([CH3:28])[NH:25][CH2:24][CH2:23]2)(=[O:17])=[O:16]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:25]3[CH2:24][CH2:23][C:22]4[C:27](=[C:18]([S:15]([CH3:14])(=[O:16])=[O:17])[CH:19]=[CH:20][CH:21]=4)[CH:26]3[CH3:28])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66876146HCID 66876146, compound

Product 1

HCID 58416490HCID 58416490, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 8-Methanesulfonyl-1-methyl-1,2,3,4-tetrahydro-isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-61ef440a87e74c39aaf5e202f8a6a896
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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