6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416344, compound

HRID 1015301Notes

Reaction equation

HRID 1015301 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][N:15]1[C:27]2[C:18](=[C:19]3[C:24](=[CH:25][CH:26]=2)[CH:23]([CH3:28])[NH:22][CH2:21][CH2:20]3)[CH:17]=[CH:16]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:22]3[CH2:21][CH2:20][C:19]4[C:24](=[CH:25][CH:26]=[C:27]5[N:15]([CH3:14])[CH:16]=[CH:17][C:18]5=4)[CH:23]3[CH3:28])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66875336HCID 66875336, compound

Product 1

HCID 58416344HCID 58416344, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 3,6-Dimethyl-6,7,8,9-tetrahydro-3H-pyrrolo[3,2-f]isoquinoline to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-295817bb25154f65b359ab1bb666e750
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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