6-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid → HCID 58416437, compound

HRID 1015303Notes

Reaction equation

HRID 1015303 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][N:15]1[C:27](=[O:28])[C:26]2[C:17](=[C:18]3[C:23](=[CH:24][CH:25]=2)[CH:22]([CH3:29])[NH:21][CH2:20][CH2:19]3)[CH2:16]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:21]3[CH2:20][CH2:19][C:18]4[C:23](=[CH:24][CH:25]=[C:26]5[C:27](=[O:28])[N:15]([CH3:14])[CH2:16][C:17]5=4)[CH:22]3[CH3:29])=[O:13])[CH:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acidHCID 66875848HCID 66875848, compound

Product 1

HCID 58416437HCID 58416437, compound

Procedure

In close analogy to the procedure described in Example 1, 6-bromo-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with 2,6-Dimethyl-1,2,6,7,8,9-hexahydro-pyrrolo[3,4-f]isoquinolin-3-one to provide the title compound in moderate yield.

Sources & evidence

ORD record
ord-4f3c395a35c948678d02de24b027300d
Source dataset
uspto-grants-2011_07
Patent number
US07985753B2

Reaction notes

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